Cosmelan 2 (6 month treatment) Mesoestetic - 30 ml

n° 1 depigmentation!

"The world's # 1 selling depigmentation treatment with millions of satisfied patients."

Cosmelan ® is the world's leading professional depigmentation method from Mesoestetic!

Cosmelan 2 is the general anti-pigmentation treatment cream for home use that works on the removal of hyperpigmentation, maintains the obtained results and prevents the appearance of new skin changes!

185.00 €

Pigmentation concerns are a growing, global issue; they affect more than 90% of adults over the age of 50. Regardless of skin color, they are a significant issue because of their unattractive appearance and negative psychological and emotional impact, affecting quality of life. Skin hyperpigmentation is caused by abnormal production of melanin, the pigment responsible for skin color, and is a consequence of uncontrolled, localized overproduction of melanin by the melanocytes, causing irregular skin coloration and dark spots. 

Depigmentation and regulation

cosmelan® is a depigmentation method that has an intensive corrective action on skin hyperpigmentations, while at the same time regulating the overproduction of melanin in the melanocytes, slowing down and controlling new dark spots. It has a dual corrective and controlling action, which achieves short and long term results by controlling hyperpigmentation.

Cosmelan 2 cream helps to prevent the appearance of new spots. Supplemented with Hydra Vital factor K and moisturizing sun protection SPF50 +, the care and prevention of stains is solved in a unique and integral way.

What is Mesoestetic Cosmelan 2?

An intensive day and night cream against pigmentation, melasma or pregnancy mask, lentigo, freckles..

Mesoestetic Cosmelan 2 is suitable for all skin types and is a cream designed to remove uneven pigmentation from the skin and restore its tone and natural glow. The advanced active formula of Cosmelan 2 limits the formation of melanin and brown spots, accelerates skin exfoliation and guarantees a more radiant, clear, even skin tone and texture.

In order to maintain and even improve the results obtained by Cosmelan 2, it is essential to use sunscreen with a sun protection factor spf greater than 50, both during the entire depigmentation process and also after its termination in order to prevent a revival of pigmentation.

Use of the Mesoestetic Cosmelan 2 cream

We recommend to use the Cosmelan 2 cream in combination with the calming effect of the Mesoestetic Melan Recovery and the protective factor of the Mesoestetic Melan 130+ pigment control. You can purchase these 3 products cheaper through this package !

Identify the facial area to be treated and apply the cream on it (avoid the eye area). Apply this a maximum of 3 times a day in the 1st month. If you notice an overreaction, reduce to twice a day. If you still notice an exaggerated skin reaction, use once a day.

The use of the Mesoestetic Cosmelan 2 can have side effects, such as:

  • Redness / Sensitivity
  • Dry Skin / Flakes
  • Burning sensation / Itching

Cosmelan 2 is a highly concentrated product, so the side effects you get from the Cosmelan 2 cream are very normal!

The cosmelan 2 cream really has a peeling effect and not every person reacts the same to it. You can try to prevent the side effects by building it up slowly by starting 1x in the evening. And if you want more intensive care, you can build up to lubricate 2x to a maximum of 3x a day.

It is recommended that you use a maximum of 0.5 ml of cream for each application. A larger amount of the cream is more difficult to absorb into the skin. Applying a thicker layer of the product can lead to skin damage such as extreme dryness, peeling of the skin, etc.


It is recommended to follow the guidelines below with Cosmelan 2 to obtain or maintain the desired result of depigmentation:

Cosmelan 2 (max 0.5 ml) is applied to clean, dry skin by a gentle massage, following the instructions of the "Mesoestetic cosmelan method protocol". This protocol provides 3 different TREATMENT METHODS, depending on your desired result or as prevention against emerging pigmentation.


  • 1 | The reduction of hyperpigmentation by continuous depigmentation: A daily routine to regulate the overproduction of melanin within the melanocyte. Apply Mesoestetic cosmelan 2 three times a day (morning, afternoon and evening), followed by Melan Recovery and moisturizing sun protection SPF 50+ throughout the day. After satisfactory results, you can switch to:
  • 2 | The control and keeping hyperpigmentation on level: Treating the overproduction of melanin by constant regulation of melanocyte. This regulates both intra- and intercellular melanin production and prevents repigmentation. Apply Mesoestetic cosmelan 2 twice a day (morning and evening) , followed by Melan Recovery and moisturizing sun protection SPF 50+ throughout the day. In case of sun exposure, reapply UV protection in the afternoon.
  • 3 | The avoidance of pigmentation and prevent new, re-pigmentation: a tendency to develop dark spots is a constant risk. During this control phase, the reappearance of the treated stains and the formation of new stains is prevented, extending the previously obtained results. Apply Mesoestetic cosmelan 2 only in the evening, followed by Melan Recovery. During the day, apply a moisturizing sunscreen SPF 50+ and reapply in case of direct sun exposure.

We recommend that you always use the sunscreen as a permanent cosmetic treatment against hyperpigmentation. With pigmentation, prevention is still much easier and cheaper than treatment.

Avoid contact with eyes and mucous membranes . In case of accidental contact - wash copiously with water.

Its use is not recommended for children under 12 years of age or during pregnancy or breastfeeding periods.


Melasma or pregnancy mask

Uneven and irregular with undefined edges. Frequently symmetrical. Shadow-like appearance.

Postinflammatory hyperpigmentation (PIH)

Irregular, flat, asymmetric spots of dark pigmentation, either localized or dispersed.

Solar and senile lentigo

Spots that are oval or round, lentil-shaped and even, measuring 2-20 millimeters.

Ephelides (freckles)

Small, flat, pigmented spots. Multiple and symmetrical. Light brown.

Our Depigmentation Products